Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

被引：127

作者：

Sohmiya, M

Tanaka, M

Tak, NW

Yanagisawa, M

Tanino, Y

Suzuki, Y

Okamoto, K

Yamamoto, Y

机构：

[1] Gunma Univ, Grad Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

[2] Univ Tokyo, Sch Engn, Dept Chem & Biotechnol, Tokyo 1138656, Japan

[3] Tokyo Univ Technol, Sch Bion, Hachioji, Tokyo 1920982, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2004年 / 223卷 / 02期

关键词：

Parkinson's disease; oxidative stress; plasma; redox status; coenzyme Q10; antioxidant;

D O I：

10.1016/j.jns.2004.05.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress market has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：161 / 166

页数：6

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