Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

被引:4405
作者
Gao, Wei [1 ,2 ,3 ]
Emaminejad, Sam [1 ,2 ,3 ,4 ]
Nyein, Hnin Yin Yin [1 ,2 ,3 ]
Challa, Samyuktha [4 ]
Chen, Kevin [1 ,2 ,3 ]
Peck, Austin [5 ]
Fahad, Hossain M. [1 ,2 ,3 ]
Ota, Hiroki [1 ,2 ,3 ]
Shiraki, Hiroshi [1 ,2 ,3 ]
Kiriya, Daisuke [1 ,2 ,3 ]
Lien, Der-Hsien [1 ,2 ,3 ]
Brooks, George A. [5 ]
Davis, Ronald W. [4 ]
Javey, Ali [1 ,2 ,3 ]
机构
[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA
[4] Stanford Genome Technol Ctr, Stanford Sch Med, Palo Alto, CA 94304 USA
[5] Univ Calif Berkeley, Integrat Biol, Berkeley, CA 94720 USA
基金
日本学术振兴会; 美国国家科学基金会; 美国国家卫生研究院;
关键词
SWEAT COMPOSITION; SKIN; LACTATE; EXERCISE; ELECTRONICS; POLYMER; DEVICES; DEHYDRATION; BIOSENSORS; PRESSURE;
D O I
10.1038/nature16521
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health(1-12). Sampling human sweat, which is rich in physiological information(13), could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state(14-18). Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.
引用
收藏
页码:509 / +
页数:18
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