Brainstem nucleus MdV mediates skilled forelimb motor tasks

被引：194

作者：

Esposito, Maria Soledad ^{[1
,2
]}

Capelli, Paolo ^{[1
,2
]}

Arber, Silvia ^{[1
,2
]}

机构：

[1] Univ Basel, Dept Cell Biol, Biozentrum, CH-4058 Basel, Switzerland

[2] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

NATURE | 2014年 / 508卷 / 7496期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

Translating the behavioural output of the nervous system into movement involves interaction between brain and spinal; cord. The brainstem provides an essential bridge between the two structures; but circuit-level organization and function; of this intermediary system remain poorly understood. Here we use intersectional virus tracing and genetic strategies in; mice to reveal a selective synaptic connectivity matrix between brainstem substructures and functionally distinct spinal; motor neurons that regulate limb movement. The brainstem nucleus medullary reticular formation ventral part (MdV); stands out as specifically targeting subpopulations of forelimb-innervating motor neurons. Its glutamatergic premotor; neurons receive synaptic input from key upper motor centres and are recruited during motor tasks. Selective neuronal; ablation or silencing experiments reveal that MdV is critically important specifically for skilled motor behaviour; including; accelerating rotarod and single-food-pellet reaching tasks. Our results indicate that distinct premotor brainstem; nuclei access spinal subcircuits to mediate task-specific aspects of motor programs; MESENCEPHALIC LOCOMOTOR REGION; SPINAL-CORD; GABAERGIC NEURONS; ORGANIZATION; ACTIVATION; MOVEMENTS; CIRCUITS; SPECIFICITY; RECOVERY; SINGLE;

D O I：

10.1038/nature13023

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Translating the behavioural output of the nervous system into movement involves interaction between brain and spinal cord. The brainstem provides an essential bridge between the two structures, but circuit-level organization and function of this intermediary system remain poorly understood. Here we use intersectional virus tracing and genetic strategies in mice to reveal a selective synaptic connectivity matrix between brainstem substructures and functionally distinct spinal motor neurons that regulate limb movement. The brainstem nucleus medullary reticular formation ventral part (MdV) stands out as specifically targeting subpopulations of forelimb-innervating motor neurons. Its glutamatergic premotor neurons receive synaptic input from key upper motor centres and are recruited during motor tasks. Selective neuronal ablation or silencing experiments reveal that MdV is critically important specifically for skilled motor behaviour, including accelerating rotarod and single-food-pellet reaching tasks. Our results indicate that distinct premotor brainstem nuclei access spinal subcircuits to mediate task-specific aspects of motor programs. © 2014 Macmillan Publishers Limited. All rights reserved.

引用

页码：351 / +

页数：18

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[1]

Circuits for Skilled Reaching and Grasping [J].