Synaptic signaling by nitric oxide

被引：280

作者：

Brenman, JE ^{[1
]}

Bredt, DS ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, PROGRAM BIOMED SCI, SAN FRANCISCO, CA 94143 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1997年 / 7卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-4388(97)80065-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic density protein PSD-95 and NMDA receptors. Characterization of this pathway has provided new insights into the role of NO in brain physiology and disease.

引用

页码：374 / 378

页数：5

共 43 条

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