The coagulo-lytic system and endothelial function in cyclosporine-treated kidney allograft recipient

Since thromboembolic complications in transplanted patients are generally attributed to combined abnormalities in platelets and coagulo-lytic system, some hemostatic parameters tPA (tissue plasminogen activator)tAg and activity, its inhibitor-PAI:Ag and activity, tPA/PAI, thrombin-antithrombin (TAT) and plasmin-antiplasmin complexes (PAP), urokinase-uPA, euglobulin clot lysis time-ECLT, fibrinogen, plasminogen, protein C activity, D-dimer, prothrombin fragments(1+2) (F-1+2), fibrin monomers, fibronectin, lipoprotein-a, and von Willebrand factor[vWF], were evaluated using commercially available kits, The studies were performed on kidney transplant recipients treated with CsA, azathioprine and prednisone (n=21), and healthy volunteers (n=21). ECLT was significantly prolonged in kidney transplant recipients together with a rise in F-1+2, lipoprotein-a, fibrinogen, fibronectin, and vWF when compared with controls, The TPA level was lower, whereas the PAI level was higher in kidney transplant recipients when compared with controls, In conclusion, CsA-treated kidney transplant recipients show evidence of pronounced impairment in fibrinolysis and endothelial damage in comparison with healthy volunteers.