Stimulated acoustic emission with the ultrasound contrast agent levovist: a clinically useful contrast effect with liver-specific properties

被引:38
作者
Albrecht, T
Blomley, MJK
Heckemann, RA
Cosgrove, DO
Jayaram, V
Butler-Barnes, J
Eckersley, RJ
Hoffmann, CW
Bauer, A
机构
[1] Free Univ Berlin, Klinikum Benjamin Franklin, Abt Radiol & Nukl Med, D-12200 Berlin, Germany
[2] Hammersmith Hosp, Imperial Coll, Dept Imaging, London, England
[3] Schering AG, Klin Entwicklung Diagnostika, D-1000 Berlin, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2000年 / 172卷 / 01期
关键词
microbubbles; ultrasound; (US); contrast media; doppler studies; liver; galactose;
D O I
10.1055/s-2000-11101
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The purpose of this study was systematically to investigate stimulated acoustic emission (SAE) with the microbubble contrast agent Levovist (Schering AG, Berlin) in vivo with regards to reproducibility, distribution in various organs over time, dependence on technical factors, and influence on the delineation of focal liver lesions. Patients and Methods: 2 intravenous injections of 1 g of Levovist were given to 2 dogs and 1-6 injections of 2.5 g Levovist to 5 healthy volunteers and 37 patients. The liver, spleen, large abdominal vessels, and kidney were intermittently scanned for up to 30 min. Studies were evaluated for the presence of SAE signals by 2 observers. In 20 patients with focal liver lesions (15 with metastases, 4 haemangiomata, 1 hepatocellular carcinoma, and 1 cyst) the influence on lesion visualization was also assessed. Results: SAE effects, lasting up to 30 minutes, were seen in all subjects in the liver and spleen. Vascular and renal SAE signals were noted shortly after injection, lasting up to 6 minutes. SAE was absent or markedly reduced in focal liver lesions, which were seen as colour voids. This increased the conspicuity of focal lesions, and in 5 patients additional metastases were detected that could not be delineated on B-mode alone. Conclusion: A liver- and spleen-specific late phase of Levovist can be consistently demonstrated using SAE and the effect increases the conspicuity of focal liver lesions.
引用
收藏
页码:61 / 67
页数:7
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