Signaling mechanistics: Aluminum fluoride for molecule of the year

被引：109

作者：

Wittinghofer, A

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(06)00355-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent three-dimensional structures of phosphoryl transfer enzymes in their aluminum fluoride bound state and corresponding biochemical data have shown how diverse biological problems can be investigated using this small inorganic molecule. (C) Current Biology Ltd ISSN 0960-9822.

引用

收藏

页码：R682 / R685

页数：4

相关论文

共 20 条

[1] Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras [J].

Ahmadian, MR ;

Stege, P ;

Scheffzek, K ;

Wittinghofer, A .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (09) :686-689

[2] ALUMINOFLUORIDE AND BERYLLOFLUORIDE COMPLEXES - NEW PHOSPHATE ANALOGS IN ENZYMOLOGY [J].

CHABRE, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (01) :6-10

[3] STRUCTURES OF ACTIVE CONFORMATIONS OF G(I-ALPHA-1) AND THE MECHANISM OF GTP HYDROLYSIS [J].

COLEMAN, DE ;

BERGHUIS, AM ;

LEE, E ;

LINDER, ME ;

GILMAN, AG ;

SPRANG, SR .

SCIENCE, 1994, 265 (5177) :1405-1412

[4] Formation and characterization of a transition state complex of Azotobacter vinelandii nitrogenase [J].

Duyvis, MG ;

Wassink, H ;

Haaker, H .

FEBS LETTERS, 1996, 380 (03) :233-236

[5] X-RAY STRUCTURES OF THE MYOSIN MOTOR DOMAIN OF DICTYOSTELIUM-DISCOIDEUM COMPLEXED WITH MGADP-CENTER-DOT-BEFX AND MGADP-CENTER-DOT-ALF4- [J].

FISHER, AJ ;

SMITH, CA ;

THODEN, JB ;

SMITH, R ;

SUTOH, K ;

HOLDEN, HM ;

RAYMENT, I .

BIOCHEMISTRY, 1995, 34 (28) :8960-8972

[6] Conformational transitions in p21(ras) and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP [J].

Geyer, M ;

Schweins, T ;

Herrmann, C ;

Prisner, T ;

Wittinghofer, A ;

Kalbitzer, HR .

BIOCHEMISTRY, 1996, 35 (32) :10308-10320

[7] NITROGENASE - A NUCLEOTIDE-DEPENDENT MOLECULAR SWITCH [J].

HOWARD, JB ;

REES, DC .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :235-264

[8] Ras-catalyzed hydrolysis of GTP: A new perspective from model studies [J].

Maegley, KA ;

Admiraal, SJ ;

Herschlag, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8160-8166

[9]

RALL TW, 1958, J BIOL CHEM, V232, P1065

[10] Aluminum fluoride inhibition of nitrogenase: Stabilization of a nucleotide center dot Fe-protein center dot MoFe-protein complex [J].

Renner, KA ;

Howard, JB .

BIOCHEMISTRY, 1996, 35 (17) :5353-5358