Agonist-stimulated calcium transients in PC12 cells are affected differentially by cadmium and nickel

被引：22

作者：

Benters, J ^{[1
]}

Schafer, T ^{[1
]}

Beyersmann, D ^{[1
]}

Hechtenberg, S ^{[1
]}

机构：

[1] UNIV BREMEN, FACHBEREICH BIOL CHEM, DEPT BIOL & CHEM, D-28359 BREMEN, GERMANY

来源：

CELL CALCIUM | 1996年 / 20卷 / 05期

关键词：

D O I：

10.1016/S0143-4160(96)90007-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rat pheochromocytoma (PC12) cells were loaded with the fluorescent indicator Fura-2 and the effects of cadmium and nickel on the mobilization of calcium elicited by bradykinin and external ATP were studied. Cadmium and nickel ions provoked a concentration-dependent decrease of the initial peak and/or the subsequent plateau phase of bradykinin-induced Ca2+ transients in a different manner: whereas cadmium (0.5-2.5 CIM) diminished the calcium peak without modifying the sustained plateau, nickel (250-1000 mu M) only slightly lowered the peak but markedly decreased the plateau phase. In the case of ATP-stimulated calcium transients, which are without a sustained plateau, both cadmium and nickel ions decreased the peak signal. Possible consequences are discussed in terms of a disturbance of hormone-stimulated cell activation by cadmium and nickel.

引用

页码：441 / 446

页数：6

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