Advancing Frontiers in Bone Bioprinting

被引：228

作者：

Ashammakhi, Nureddin ^{[1
,2
,3
,4
]}

Hasan, Anwarul ^{[5
,6
]}

Kaarela, Outi ^{[4
]}

Byambaa, Batzaya ^{[7
,8
]}

Sheikhi, Amir ^{[1
]}

Gaharwar, Akhilesh K. ^{[9
,10
]}

Khademhosseini, Ali ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, C MIT, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, CNSI, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[4] Oulu Univ Hosp, Dept Surg, Div Plast Surg, FI-90014 Oulu, Finland

[5] Qatar Univ, Coll Engn, Dept Mech & Ind Engn, Doha 2713, Qatar

[6] Qatar Univ, Biomed Res Ctr, Doha 2713, Qatar

[7] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Ctr Biomed Engn, Cambridge, MA 02115 USA

[8] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[9] Texas A&M Univ, Dept Biomed Engn, Dept Mat Sci & Engn, College Stn, TX 77841 USA

[10] Texas A&M Univ, Ctr Remote Hlth & Technol, College Stn, TX 77841 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2019年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

3D bioprinting; bioinks; bone defects; tissue engineering; MESENCHYMAL STEM-CELLS; 3D PRINTED SCAFFOLDS; PHOTO-CROSS-LINKING; TISSUE CONSTRUCTS; MATRIX ELASTICITY; CARTILAGE TISSUE; HYDROGEL; LADEN; FABRICATION; ALGINATE;

D O I：

10.1002/adhm.201801048

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Three-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.

引用

页数：24

共 172 条

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