Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons

被引：18

作者：

Andrews, ZB

Grattan, DR

机构：

[1] Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, Dunedin, New Zealand

[2] Univ Otago, Sch Med Sci, Neurosci Res Ctr, Dunedin, New Zealand

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 01期

关键词：

late pregnancy; prolactin; tuberoinfundibular dopamine neurons; opioids; naloxone; antepartum;

D O I：

10.1016/S0304-3940(02)00431-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prolactin (PRL) secretion from the anterior pituitary is tonically inhibited by tuberoinfundibular cloparnine (TIDA) neurons in the arcuate nucleus of the hypothalamus. During late pregnancy, TIDA neuronal activity is reduced allowing the expression of an antepartum PRL surge. We show here that continuous infusion of the opioid receptor antagonist naloxone (10 mg/h) during the night preceding parturition completely abolished the antepartum PRL surge and significantly increased TIDA neuronal activity. These data indicate that endogenous opioid neurons facilitate PRL secretion at the end of pregnancy by suppressing TIDA neuronal activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：60 / 64

页数：5

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