Coupling between neuronal and glial cells via glutamate metabolism in brain of healthy persons and patients with mental disorders

被引：11

作者：

Boksha, IS ^{[1
]}

机构：

[1] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 117152, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2004年 / 69卷 / 07期

关键词：

glutamate metabolism; human brain; mental disorders;

D O I：

10.1023/B:BIRY.0000040194.97348.e7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This review summarizes general considerations on glutamate metabolism in human brain. Biochemical coupling between neurons and glia is discussed with respect to glutamate metabolism and its compartmentation. Glutamate recycling and the role of key glutamate-metabolizing enzymes are viewed. Alterations in components of glutamatergic system and glutamate metabolizing enzymes are considered with reference to mental disorders such as senile dementia of Alzheimer's type and schizophrenia.

引用

页码：705 / 719

页数：15

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