Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids

被引：32

作者：

Enderlin, V

Alfos, S

Pallet, V

Garcin, H

AzaisBraesco, V

Jaffard, R

Higueret, P

机构：

[1] UNIV BORDEAUX 1, ISTAB, LAB NUTR, F-33405 TALENCE, FRANCE

[2] INRA, CTR RECH NUTR HUMAINE, F-63009 CLERMONT FERRAND, FRANCE

[3] UNIV BORDEAUX 1, LAB NEUROSCI COMPORTEMENTALES & COGNIT, F-33405 TALENCE, FRANCE

来源：

FEBS LETTERS | 1997年 / 412卷 / 03期

关键词：

aging; nuclear receptor; RAR; TR; mRNA; retinoid;

D O I：

10.1016/S0014-5793(97)00845-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is accompanied by troubles resulting from changes in hormonal and nutritional status, Therefore, the abundance of mRNA coding for triiodothyronine (TR) and retinoic acid (EW) nuclear receptors was studied in the brain of young, adult and aged (2.5, 6 and 24 months, respectively) rats, In the brain of aged rats, there mas a lower abundance of TR and RAR mRNA and a loner activity of tissue transglutaminase (tTG), an enzyme the gene of which is a target for retinoids, Administration of RA in these rats restored TR and RAR mRNA and the activity of tTG in the brain, The importance of these observations to the function of the aged brain is discussed. (C) 1997 Federation of European Biochemical Societies.

引用

页码：629 / 632

页数：4

共 34 条

[1] Chronic ethanol consumption increases the amount of mRNA for retinoic acid and triiodothyronine receptors in mouse brain [J].