Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

被引：115

作者：

Deshpande, Aniruddha J.

Cusan, Monica

Rawat, Vijay P. S.

Reuter, Hendrik

Krause, Alexandre

Pott, Christiane

Quintanilla-Martinez, Leticia

Kakadia, Purvi

Kuchenbauer, Florian

Ahmed, Farid

Delabesse, Eric

Hahn, Meinhard

Lichter, Peter

Kneba, Michael

Hiddemann, Wolfgang

Macintyre, Elizabeth

Mecucci, Cristina

Ludwig, Wolf-Dieter

Humphries, R. Keith

Bohlander, Stefan K.

Feuring-Buske, Michaela

Buske, Christian ^{[1
]}

机构：

[1] Univ Munich, Klinikum Grosshadern, Dept Med 3, D-81377 Munich, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Clin Cooperat Grp Leukemia, D-81377 Munich, Germany

[3] German Canc Res Ctr, Div Mol Genet, D-69120 Heidelberg, Germany

[4] Univ Kiel, Hosp Schleswig Holstein, Dept Med 2, D-24116 Kiel, Germany

[5] GSF, Inst Pathol, D-85758 Neuherberg, Germany

[6] Univ Perugia, Hematol & Bone Marrow Transplantat Unit, I-06122 Perugia, Italy

[7] Robert Rossle Klin, Dept Hematol Oncol & Tumor Immunol, D-13125 Berlin, Germany

[8] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

[9] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1L3, Canada

来源：

CANCER CELL | 2006年 / 10卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2006.08.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. Furthermore, depletion of B220+ cells in leukemic transplants impaired development of leukemia in recipients. As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells. These data demonstrate in a murine leukemia model that AIVIL can be propagated by a transformed progenitor with lymphoid characteristics, which can be targeted by antibodies that do not crossreact with normal HSCs.

引用

页码：363 / 374

页数：12

共 47 条

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