Extinction circuits for fear and addiction overlap in prefrontal cortex
被引:580
作者:
Peters, Jamie
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Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
Univ Puerto Rico, Sch Med, Dept Anat & Neurobiol, San Juan, PR 00936 USAUniv Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
Peters, Jamie
[1
,2
]
Kalivas, Peter W.
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Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USAUniv Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
Kalivas, Peter W.
[3
]
Quirk, Gregory J.
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Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
Univ Puerto Rico, Sch Med, Dept Anat & Neurobiol, San Juan, PR 00936 USAUniv Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
Quirk, Gregory J.
[1
,2
]
机构:
[1] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00936 USA
[2] Univ Puerto Rico, Sch Med, Dept Anat & Neurobiol, San Juan, PR 00936 USA
[3] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is critical for the extinction of both fear and drug-seeking behaviors. Moreover, a dorsal-ventral distinction is apparent within the mPFC, such that the prelimbic (PL-mPFC) cortex drives the expression of fear and drug seeking, whereas the infralimbic (IL-mPFC) cortex suppresses these behaviors after extinction. For conditioned fear, the dorsal-ventral dichotomy is accomplished via divergent projections to different subregions of the amygdala, whereas for drug seeking, it is accomplished via divergent projections to the subregions of the nucleus accumbens. Given that the mPFC represents a common node in the extinction circuit for these behaviors, treatments that target this region may help alleviate symptoms of both anxiety and addictive disorders by enhancing extinction memory.
机构:
Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
Anderson, SW
;
Damasio, H
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Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
Damasio, H
;
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Tranel, D
;
Damasio, AR
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Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
机构:
Univ So Calif, Dept Psychol, Inst Neurol Study Emot & Creat, Los Angeles, CA 90089 USAUniv So Calif, Dept Psychol, Inst Neurol Study Emot & Creat, Los Angeles, CA 90089 USA
机构:
Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
Anderson, SW
;
Damasio, H
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机构:
Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
Damasio, H
;
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机构:
Tranel, D
;
Damasio, AR
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USAUniv Iowa, Div Behav Neurol & Cognit Neurosci, Dept Neurol, Iowa City, IA 52242 USA
机构:
Univ So Calif, Dept Psychol, Inst Neurol Study Emot & Creat, Los Angeles, CA 90089 USAUniv So Calif, Dept Psychol, Inst Neurol Study Emot & Creat, Los Angeles, CA 90089 USA