Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

被引：280

作者：

West, Anthony P., Jr. ^{[1
]}

Scharf, Louise ^{[1
]}

Scheid, Johannes F. ^{[2
]}

Klein, Florian ^{[2
]}

Bjorkman, Pamela J. ^{[1
,3
]}

Nussenzweig, Michel C. ^{[2
,4
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

[3] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

[4] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

CELL | 2014年 / 156卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; HUMAN MONOCLONAL-ANTIBODY; PROXIMAL EXTERNAL REGION; N-GLYCAN RECOGNITION; B-CELL RESPONSES; ENVELOPE GLYCOPROTEIN; CD4-BINDING SITE; CONFORMATIONAL EPITOPE; ANTIRETROVIRAL THERAPY;

D O I：

10.1016/j.cell.2014.01.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.

引用

页码：633 / 648

页数：16

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