Temporal stability of acute stress-induced changes in leukocyte subsets and cellular adhesion molecules in older adults

被引:18
作者
Adler, KA
Mills, PJ [1 ]
Dimsdale, JE
Ziegler, MG
Patterson, TL
Sloan, RP
Grant, I
机构
[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] San Diego State Univ, Dept Psychol, San Diego, CA 92192 USA
[4] Columbia Univ, Behav Med Program, New York, NY 10027 USA
关键词
temporal stability; stress; leukocytes; adhesion molecules; CD62L; CD11a; Alzheimer's caregivers; older adults;
D O I
10.1006/brbi.2001.0630
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study investigated the temporal stability of enumerative immune and catecholamine responses to acute psychosocial stress in 67 Alzheimer's caregivers ages 56-82 years (45 women and 22 men) who were required to prepare and deliver two 3-min speeches on three occasions at 2-week and 6-week intervals. All leukocyte subsets and adhesion molecules (CD62L and CD 1 la) changed significantly from rest to postspeak at each of the three testing sessions (p's < .0005). Responses showed moderate to high temporal stability across baseline and absolute task values (r's = .65-96). Reliability was predictably lower for both forms of change scores (r's = -.16-64). The level of temporal stability achieved is comparable to that seen previously in younger adults, indicating that acute psychosocial, leukocytes and cell adhesion molecules in stress produces reliable changes in circulating older adults. (C) 2001 Elsevier Science (USA).
引用
收藏
页码:262 / 274
页数:13
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