Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

被引：198

作者：

Baillie, George S. ^{[1
]}

机构：

[1] Univ Glasgow, Div Neurosci & Mol Pharmacol, Glasgow G12 8QQ, Lanark, Scotland

来源：

FEBS JOURNAL | 2009年 / 276卷 / 07期

基金：

英国医学研究理事会;

关键词：

cAMP; compartmentalization; compartmentalized signalling; EPAC; FRET; G-protein coupled receptor; PDE; PDE4; PKA; DEPENDENT PROTEIN-KINASE; RAT VENTRICULAR MYOCYTES; N-TERMINAL REGION; CYCLIC-AMP; CARDIAC MYOCYTES; BETA-ARRESTINS; LIVING CELLS; IMMUNOHISTOCHEMICAL LOCALIZATION; BETA(2)-ADRENERGIC RECEPTORS; MEMBRANE ASSOCIATION;

D O I：

10.1111/j.1742-4658.2009.06926.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phosphodiesterases that act as sinks to create simultaneous, multiple cAMP gradients in many cellular locations. Such gradients are sampled within microdomains that contain anchored cAMP effector proteins. Compartmentalization of proteins that produce, degrade and are activated by cAMP is crucial for the specificity of action required for normal cell function.

引用

收藏

页码：1790 / 1799

页数：10

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