Deoxyribozymes: new players in the ancient game of biocatalysis

被引：126

作者：

Li, YF ^{[1
]}

Breaker, RR ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(99)80042-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The repetitive and extraordinarily stable polynucleotide chains of DNA serve as an ideal storage system for genetic information. Although it is best known for its helical structure and relatively inert character, in vitro selection can be used to compel DNA to perform a surprising variety of chemical reactions, These artificial DNA enzymes or 'deoxyribozymes' generate large chemical rate enhancements and demonstrate precise substrate recognition, much like their protein and RNA counterparts. Recent studies with these prototypic deoxyribozymes indicate that DNA has a substantial untapped potential for intricate structure formation that could be exploited in novel chemical and biological catalysis.

引用

页码：315 / 323

页数：9

共 62 条

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