Gaining entry to an uninflamed brain

被引：44

作者：

Axtell, Robert C. ^{[1
]}

Steinman, Lawrence ^{[1
]}

机构：

[1] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 05期

关键词：

CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; INFLAMMATION; INDUCTION; CELLS;

D O I：

10.1038/ni0509-453

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about how pathogenic T cells gain access to the uninflamed brain in multiple sclerosis and experimental autoimmune encephalomyelitis. A new study reports that interleukin 17-producing T helper cells enter the uninflamed central nervous system through the choroid plexus by a CCR6-CCL20-dependent mechanism.

引用

页码：453 / 455

页数：4

共 17 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2] Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis [J].

Bettelli, E ;

Sullivan, B ;

Szabo, SJ ;

Sobel, RA ;

Glimcher, H ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (01) :79-87

[3] Cytokines and fever [J].

Conti, B ;

Tabarean, I ;

Andrei, C ;

Bartfai, T .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 :1433-1449

[4]

Engelhardt B, 2001, MICROSC RES TECHNIQ, V52, P112, DOI 10.1002/1097-0029(20010101)52:1<112::AID-JEMT13>3.0.CO

[5]

2-5

[6] IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination [J].

Gran, B ;

Zhang, GX ;

Yu, S ;

Li, JF ;

Chen, XH ;

Ventura, ES ;

Kamoun, M ;

Rostami, A .

JOURNAL OF IMMUNOLOGY, 2002, 169 (12) :7104-7110

[7] IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice [J].

Haak, Stefan ;

Croxford, Andrew L. ;

Kreymborg, Katharina ;

Heppner, Frank L. ;

Pouly, Sandrine ;

Becher, Burkhard ;

Waisman, Ari .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) :61-69

[8] Anti-Inflammatory Role of IL-17 in Experimental Autoimmune Uveitis [J].

Ke, Yan ;

Liu, Ke ;

Huang, Guo-Qiang ;

Cui, Yan ;

Kaplan, Henry J. ;

Shao, Hui ;

Sun, Deming .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :3183-3190

[9] IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].

Langrish, CL ;

Chen, Y ;

Blumenschein, WM ;

Mattson, J ;

Basham, B ;

Sedgwick, JD ;

McClanahan, T ;

Kastelein, RA ;

Cua, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240

[10]

PANITCH HS, 1987, LANCET, V1, P893

← 1 2 →