High quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7 Tesla

被引：48

作者：

Krishnamoorthy, Guruprasad ^{[2
]}

Nanga, Ravi Prakash Reddy ^{[1
]}

Bagga, Puneet ^{[1
]}

Hariharan, Hari ^{[1
]}

Reddy, Ravinder ^{[1
]}

机构：

[1] Univ Penn, Dept Radiol, CMROI, Philadelphia, PA 19104 USA

[2] Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands

来源：

MAGNETIC RESONANCE IN MEDICINE | 2017年 / 77卷 / 05期

关键词：

3D gagCEST; magnetization preparation 3D; B-1; calibration; B-0; EXCHANGE SATURATION-TRANSFER; HUMAN ARTICULAR-CARTILAGE; 3; T;

D O I：

10.1002/mrm.26265

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

PurposeTo develop a new faster and higher quality three-dimensional (3D) gagCEST MRI technique for reliable quantification of glycosaminoglycan (GAG) present in the human knee cartilages. MethodsA new magnetization-prepared 3D gradient echo-based MRI pulse sequence has been designed to obtain the B-0 inhomogeneity, B-1 inhomogeneity, and CEST Z-spectra images. ResultsThe gagCEST values of different compartments of knee cartilage are calculated using a newly developed technique for healthy subjects and a symptomatic knee cartilage degenerated subject. The effect of the acquired CEST saturation frequency offset step-size was investigated to establish the optimal step-size to obtain reproducible gagCEST maps. Our novel 3D gagCEST technique demonstrates markedly higher gagCEST contrast value than the previously reported 3D gagCEST studies. This study demonstrates the need for separate B-0 and B-1 inhomogeneity estimation and correction. ConclusionThe new technique provided high quality gagCEST maps with clearer visualization of different layers of knee cartilage with reproducible results. Magn Reson Med 77:1866-1873, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine

引用

页码：1866 / 1873

页数：8

共 18 条

[1]

Feasibility of T2* Mapping for the Evaluation of Hip Joint Cartilage at 1.5T Using a Three-Dimensional (3D), Gradient-Echo (GRE) Sequence: A Prospective Study [J].