Polybromo-1: The chromatin targeting subunit of the PBAF complex

被引：85

作者：

Thompson, Martin ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

来源：

BIOCHIMIE | 2009年 / 91卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Polybromo; BAF180; PBAF; Bromodomain; NUCLEOSOME-REMODELING COMPLEX; STRUCTURAL BASIS; HISTONE ACETYLATION; BAH DOMAIN; TRANSCRIPTION FACTORS; RECOGNITION COMPLEX; CRITICAL REGULATOR; NUCLEAR RECEPTORS; TUMOR-SUPPRESSOR; ORC1; PROTEIN;

D O I：

10.1016/j.biochi.2008.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. Pb1 coordinates key features common to all remodeling complexes, including chromatin localization, recruitment of protein subunits and alteration of chromatin architecture. A comprehensive analysis of individual domains composing Pb1 is used to propose new information regarding the function of Pb1 in the PBAF chromatin-remodeling complex. The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：309 / 319

页数：11

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