Update on mesenchymal stem cell-based therapy in lupus and scleroderma

被引：67

作者：

Cras, Audrey ^{[1
,2
,3
]}

Farge, Dominique ^{[4
]}

Carmoi, Thierry ^{[5
]}

Lataillade, Jean-Jacques ^{[6
]}

Wang, Dan Dan ^{[7
]}

Sun, Lingyun ^{[7
]}

机构：

[1] St Louis Hosp, AP HP, Cell Therapy Unit, Cord Blood Bank, F-75010 Paris, France

[2] CIC BT501, F-75010 Paris, France

[3] Fac Pharm, Paris Descartes, INSERM UMRS 1140, F-75004 Paris, France

[4] Univ Paris 07, St Louis Hosp, AP HP,CIC BT501,INSERM UMRS 1160, Sorbonne Paris Cite,Internal Med & Vasc Dis Unit, F-75010 Paris, France

[5] Hop Val De Grace, Internal Med Unit, F-75005 Paris, France

[6] Percy Mil Hosp, Dept Res & Cell Therapy, F-92140 Clamart, France

[7] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Immunol, Nanjing 210008, Jiangsu, Peoples R China

来源：

ARTHRITIS RESEARCH & THERAPY | 2015年 / 17卷

关键词：

HUMAN BONE-MARROW; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROGRESSIVE SYSTEMIC-SCLEROSIS; STROMAL CELLS; IMMUNOMODULATORY PROPERTIES; PULSE CYCLOPHOSPHAMIDE; MYCOPHENOLATE-MOFETIL; ANTIBODY-PRODUCTION; HEALTHY DONORS; EUROPEAN GROUP;

D O I：

10.1186/s13075-015-0819-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15 years, autologous hematopoietic stem cell transplantation has been demonstrated to cure some patients with severe AD refractory to all other available therapies. As a consequence, ADs such as lupus and scleroderma have become an emerging indication for cell therapy. Multipotent mesenchymal stem cells (MSCs), isolated from bone marrow and other sites, display specific immunomodulation and anti-inflammatory properties and appear as ideal tools to treat such diseases. The present update aims at summarizing recent knowledge acquired in the field of MSC-based therapies for lupus and scleroderma.

引用

页数：9

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