Acetaminophen Hepatotoxicity and Acute Liver Failure

被引：236

作者：

Chun, Linda J. ^{[1
]}

Tong, Myron J. ^{[3
]}

Busuttil, Ronald W. ^{[2
]}

Hiatt, Jonathan R. ^{[2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Albert Einstein Coll Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Digest Dis,Pfleger Liver Inst, Los Angeles, CA 90095 USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2009年 / 43卷 / 04期

关键词：

acute liver failure; drug toxicity; liver transplantation; FULMINANT HEPATIC-FAILURE; N-ACETYLCYSTEINE; MEDICAL PROGRESS; EARLY INDICATORS; PROTEIN ADDUCTS; TRANSPLANTATION; MANAGEMENT; MULTICENTER; OVERDOSE; CARE;

D O I：

10.1097/MCG.0b013e31818a3854

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews Current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

引用

页码：342 / 349

页数：8

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