The mechanism(s) of hypoxic pulmonary vasoconstriction:: Potassium channels, redox O2 sensors, and controversies

被引：117

作者：

Archer, S ^{[1
]}

Michelakis, E

机构：

[1] Univ Alberta, Dept Med Cardiol, Edmonton, AB T6G 2B7, Canada

[2] Univ Alberta, Vasc Biol Grp, Edmonton, AB T6G 2B7, Canada

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01388.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in Pot are sensed by a vascular redox O-2 sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K+ channels, thereby controlling membrane potential, Ca2+ entry, and tone.

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页码：131 / 137

页数：7

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