Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon beta-1a (IFN beta-1a) products administered intramuscularly in healthy male and female volunteers

被引：62

作者：

Alam, J

Goelz, S

Rioux, P

Scaramucci, J

Jones, W

McAllister, A

Campion, M

Rogge, M

机构：

[1] BIOGEN INC,PRECLIN DEV,CAMBRIDGE,MA 02142

[2] BIOGEN INC,BIOASSAY,CAMBRIDGE,MA 02142

[3] BIOGEN INC,MED AFFAIRS,CAMBRIDGE,MA 02142

[4] BIOGEN INC,CELLULAR BIOCHEM,CAMBRIDGE,MA 02142

[5] BIOGEN INC,MED AFFAIRS,F-92101 NANTERRE,FRANCE

来源：

PHARMACEUTICAL RESEARCH | 1997年 / 14卷 / 04期

关键词：

Avonex(TM); Rebif(R); interferon-beta-1a; pharmacokinetics; pharmacodynamics;

D O I：

10.1023/A:1012128406432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：546 / 549

页数：4

共 16 条

[1] ALAM J, 1991, Journal of Interferon Research, V11, pS246
[2] INTERFERON-BETA TREATMENT OF HUMAN-DISEASE
ALAM, JJ
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 1995, 6 (06) : 688 - 691
[3] THE INTERFERONS - MECHANISMS OF ACTION AND CLINICAL-APPLICATIONS
BARON, S
TYRING, SK
FLEISCHMANN, WR
COPPENHAVER, DH
NIESEL, DW
KLIMPEL, GR
STANTON, GJ
HUGHES, TK
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (10): : 1375 - 1383
[4] A highly precise reporter gene bioassay for type I interferon
Canosi, U
Mascia, M
Gazza, L
SerlupiCrescenzi, O
Donini, S
Antonetti, F
Galli, G
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 199 (01) : 69 - 76
[5] PHARMACOKINETICS OF RECOMBINANT HUMAN INTERFERON-BETA(SER) IN HEALTHY-VOLUNTEERS AND ITS EFFECT ON SERUM NEOPTERIN
CHIANG, J
GLOFF, CA
YOSHIZAWA, CN
WILLIAMS, GJ
[J]. PHARMACEUTICAL RESEARCH, 1993, 10 (04) : 567 - 572
[6] PHARMACOKINETICS AND ANTIVIRAL ACTIVITY OF RECOMBINANT HUMAN INTERFERON-BETA(SER17) IN AFRICAN-GREEN MONKEYS
CHIANG, J
GLOFF, CA
SOIKE, KF
WILLIAMS, G
[J]. JOURNAL OF INTERFERON RESEARCH, 1993, 13 (02): : 111 - 120
[7] THE ROLE OF NEOPTERIN AS A MONITOR OF CELLULAR IMMUNE ACTIVATION IN TRANSPLANTATION, INFLAMMATORY, INFECTIOUS, AND MALIGNANT DISEASES
FUCHS, D
WEISS, G
REIBNEGGER, G
WACHTER, H
[J]. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 1992, 29 (3-4) : 307 - 341
[8] Intramuscular interferon beta-1 alpha for disease progression in relapsing multiple sclerosis
Jacobs, LD
Cookfair, DL
Rudick, RA
Herndon, RM
Richert, JR
Salazar, AM
Fischer, JS
Goodkin, DE
Granger, CV
Simon, JH
Alam, JJ
Bartoszak, DM
Bourdette, DN
Braiman, J
Brownscheidle, CM
Coats, ME
Cohan, SL
Dougherty, DS
Kinkel, RP
Mass, MK
Munschauer, FE
Priore, RL
Pullicino, PM
Scherokman, BJ
WeinstockGuttman, B
Whitman, RH
Baird, WC
Fillmore, M
Bona, LM
ColonRuiz, ME
Nadine, BS
Donovan, A
Bennett, S
Kieffer, YM
Umhauer, MA
Miller, CE
Kilic, AK
Sargent, EL
Schachter, M
Shucard, DW
Weider, V
Catalano, BA
Cervi, JM
Czekay, C
Farrell, JL
Filippini, JS
Matyas, RC
Michienzi, KE
Ito, M
OMalley, JA
[J]. ANNALS OF NEUROLOGY, 1996, 39 (03) : 285 - 294
[9] KENWARD MG, 1989, DESIGN ANAL CROSS OV
[10] DOUBLE-BLIND RANDOMIZED PHASE-I STUDY ON THE CLINICAL TOLERANCE AND BIOLOGICAL EFFECTS OF NATURAL AND RECOMBINANT INTERFERON-BETA
LIBERATI, AM
HORISBERGER, MA
PALMISANO, L
ASTOLFI, S
NASTARI, A
MECHATI, S
VILLA, A
MANCINI, S
ARZANO, S
GRIGNANI, F
[J]. JOURNAL OF INTERFERON RESEARCH, 1992, 12 (05): : 329 - 336

← 1 2 →