The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson's Disease

被引：1046

作者：

Barone, Paolo ^{[2
,3
]}

Antonini, Angelo ^{[1
]}

Colosimo, Carlo ^{[4
]}

Marconi, Roberto ^{[5
]}

Morgante, Letterio ^{[6
]}

Avarello, Tania P. ^{[7
]}

Bottacchi, Eugenio ^{[8
]}

Cannas, Antonino ^{[9
]}

Ceravolo, Gabriella ^{[10
]}

Ceravolo, Roberto ^{[11
]}

Cicarelli, Giulio ^{[12
]}

Gaglio, Roberto M. ^{[13
]}

Giglia, Rosa M. ^{[14
]}

Iemolo, Francesco ^{[15
]}

Manfredi, Michela ^{[16
]}

Meco, Giuseppe ^{[4
]}

Nicoletti, Alessandra ^{[17
]}

Pederzoli, Massimo ^{[18
]}

Petrone, Alfredo ^{[19
]}

Pisani, Antonio ^{[20
]}

Ponfieri, Francesco E. ^{[21
]}

Quatrale, Rocco ^{[22
]}

Ramat, Silvia ^{[23
]}

Scala, Rosanna ^{[24
]}

Volpe, Giuseppe ^{[25
]}

Zappulla, Salvatore ^{[26
]}

Bentivoglio, Anna Rita ^{[27
]}

Stocchi, Fabrizio ^{[28
]}

Trianni, Giorgio ^{[29
]}

Del Dotto, Paolo ^{[30
]}

机构：

[1] Parkinson Inst, Ist Clin Perfezionamento, I-20126 Milan, Italy

[2] Univ Naples Federico 2, Naples, Italy

[3] IDC Hermitage Capodimonte, Naples, Italy

[4] Univ Roma La Sapienza, Dipartimento Sci Neurol, Rome, Italy

[5] Osped Misericordia, Grosseto, Italy

[6] Univ Messina, Dipartimento Neurosci Sci Psichiat & Anestesiol, I-98100 Messina, Italy

[7] Osped Villa Sofia CTO, Palermo, Italy

[8] Osped Reg, UO Neurol, Aosta, Italy

[9] Policlin Univ, Neurol Clin, Cagliari, Italy

[10] Osped Umberto 1, Clin Neuroriabilitaz, Ancona, Italy

[11] Osped Santa Chiara, Pisa, Italy

[12] AORN San Giuseppe Moscati, Avellino, Italy

[13] Azienda Osped S Giovanni Dio, UO Neurol, Agrigento, Italy

[14] Azienda Osped S Elia, Caltanissetta, Italy

[15] Osped Guzzardi, UO Neurol, Ragusa, Italy

[16] Fdn Salvatore Maugeri IRCCS, Mantova, Italy

[17] Policlin Uni, Clin Neurol 1, Catania, Italy

[18] Osped Civile, Milan, Italy

[19] Presidio Osped Anmmziata, Cosenza, Italy

[20] IRCCS, Fdn Santa Lucia, Policlin Tor Vergata, Rome, Italy

[21] Univ Roma La Sapienza, Osped St Andrea, Rome, Italy

[22] Osped St Anna, Neurol Dipartimento Neurosci Applicate Clin, Ferrara, Italy

[23] Azienda Osped Univ, Neurol Clin, Florence, Italy

[24] Osped S Maria Loreto Nuovo, Naples, Italy

[25] Presidio Osped S Luca, Neurofisiopatol Dipartimento Neuro Orto Traumatol, Salerno, Italy

[26] Osped Umberto 1, Enna, Italy

[27] Univ Cattolica Sacro Cuore, Neurol Clin, Rome, Italy

[28] IRCCS San Raffaele, Rome, Italy

[29] POF Ferrari, Lecce, Italy

[30] Osped Versilia, UO Neurol, Camaiore, Italy

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 11期

关键词：

nonmotor symptoms; Parkinson's disease; quality of life; cognition; psychiatric symptoms; FRONTAL ASSESSMENT BATTERY; DIAGNOSTIC-CRITERIA; DEPRESSION; FATIGUE; QUESTIONNAIRE; SAMPLE; ONSET; FAB;

D O I：

10.1002/mds.22643

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed a multicenter survey using a semi-structured interview in 1,072 consecutive patients with Par kinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment. and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (39%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. (C) 2009 Movement Disorder Society

引用

页码：1641 / 1649

页数：9

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