Determination of the steady state tissue distribution of midazolam in the rat

被引：25

作者：

Bjorkman, S ^{[1
]}

Fyge, A ^{[1
]}

Qi, ZQ ^{[1
]}

机构：

[1] MALMO UNIV HOSP,DEPT EXPT RES,MALMO,SWEDEN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1996年 / 85卷 / 08期

关键词：

D O I：

10.1021/js960113+

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to determine the steady state tissue:blood (k(b)), tissue:plasma (k(p)), and tissue:plasma water (k(u)) partition coefficients of midazolam in all major organs and tissues in the rat, after development of a gas chromatographic assay. The k(p) in 12 tissues ranged between 1.3 (in muscle) and 9.0 (in fat), k(u) ranged correspondingly between 16 and 115.

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页码：887 / 889

页数：3

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