Investigation on bioactivity and cytotoxicity of mesoporous nano-composite MCM-48/hydroxyapatite for ibuprofen drug delivery

被引：68

作者：

Aghaei, Hoda ^{[1
]}

Nourbakhsh, Amir Abbas ^{[2
]}

Karbasi, Saeed ^{[3
]}

JavadKalbasi, Roozbeh ^{[4
]}

Rafienia, Mohammad ^{[5
]}

Nourbakhsh, Nosrat ^{[6
]}

Bonakdar, Shahin ^{[7
]}

Mackenzie, Kenneth J. D. ^{[8
]}

机构：

[1] Islamic Azad Univ, Dept Mat Engn, Najafabad Branch, Esfahan, Iran

[2] Islamic Azad Univ, Shahreza Branch, Dept Mat Engn, Esfahan 86137, Iran

[3] Adv Med Technol Dept, Biomat Nanotechnol & Tissue Engn Grp, Esfahan, Iran

[4] Islamic Azad Univ, Shahreza Branch, Dept Chem, Esfahan 86137, Iran

[5] Isfahan Univ Med Sci, Biosensor Res Ctr, Esfahan 817473461, Iran

[6] Isfahan Univ Med Sci, Torabinejad Dent Res Ctr, Sch Dent, Dept Pediat Dent, Esfahan 817473461, Iran

[7] Pasteur Inst Iran, Natl Cell Bank Iran, Tehran 1316943551, Iran

[8] Victoria Univ Wellington, MacDiarmid Inst Adv Mat & Nanotechnol, Wellington 6140, New Zealand

来源：

CERAMICS INTERNATIONAL | 2014年 / 40卷 / 05期

关键词：

Mesoporous MCM-48; Hydroxyapatite; Bioactive materials; Drug delivery; CONTROLLED-RELEASE; HYDROXYAPATITE; PROPERTY; SILICATE; SULFATE; CELLS;

D O I：

10.1016/j.ceramint.2013.12.079

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

081705 [工业催化]; 082905 [生物质能源与材料];

摘要：

A novel in situ synthesis is presented of a hydroxyapatite composite with the mesoporous silicate MCM-48 with potential applications as a drug delivery agent The structure and properties of this nanocomposite, investigated by a number of techniques including XRD, SEM and TEM, show the intergrowth of the hydroxyapatite particles with the silica structure. The bioactivity of the new material was determined by measuring the decrease in the calcium ion concentration of simulated body fluid (SBF) after soaking the nanocomposite, while the uptake of ibuprofen on MCM-48 and MCM-48/HAp composite from ethanol was monitored by UV spectroscopy at 222 nm which was also used to monitor the release of ibuprofen into SBF, MTT assay was used to assess effect of the sample on MG68 cell live proliferation. The results confirm the successful synthesis of a MCM-48/hydroxyapatite nanocomposite and its potential biomedical applications as a bioactive ceramic and as a drug delivery agent with a higher rate of ibuprofen release compared to MCM-48. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：7355 / 7362

页数：8

共 35 条

[1]

Structure of MCM-48 revealed by transmission electron microscopy [J].

Alfredsson, V ;

Anderson, MW .

CHEMISTRY OF MATERIALS, 1996, 8 (05) :1141-1146

[2]

Aufdembrick B. A., 1993, U. S. Patent, Patent No. [5258114, 5,258,114]

[3]

A NEW FAMILY OF MESOPOROUS MOLECULAR-SIEVES PREPARED WITH LIQUID-CRYSTAL TEMPLATES [J].

BECK, JS ;

VARTULI, JC ;

ROTH, WJ ;

LEONOWICZ, ME ;

KRESGE, CT ;

SCHMITT, KD ;

CHU, CTW ;

OLSON, DH ;

SHEPPARD, EW ;

MCCULLEN, SB ;

HIGGINS, JB ;

SCHLENKER, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) :10834-10843

[4]

In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane [J].

Bedouet, Laurent ;

Pascale, Florentina ;

Bonneau, Michel ;

Wassef, Michel ;

Laurent, Alexandre .

TOXICOLOGY IN VITRO, 2011, 25 (08) :1944-1952

[5]

Bohner M, 2000, INJURY, V31, pS37

[6]

Controlled release of biomolecules from temperature-sensitive hydrogels prepared by radiation polymerization [J].

Caliceti, P ;

Salmaso, S ;

Lante, A ;

Yoshida, M ;

Katakai, R ;

Martellini, F ;

Mei, LHI ;

Carenza, M .

JOURNAL OF CONTROLLED RELEASE, 2001, 75 (1-2) :173-181

[7]

The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro [J].

Changez, M ;

Burugapalli, K ;

Koul, V ;

Choudhary, V .

BIOMATERIALS, 2003, 24 (04) :527-536

[8]

A new method to produce macropores in calcium phosphate cements [J].

del Real, RP ;

Wolke, JGC ;

Vallet-Regí, M ;

Jansen, JA .

BIOMATERIALS, 2002, 23 (17) :3673-3680

[9]

Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery [J].

Gao, Lin ;

Sun, Jihong ;

Zhang, Li ;

Wang, Jinpeng ;

Ren, Bo .

MATERIALS CHEMISTRY AND PHYSICS, 2012, 135 (2-3) :786-797

[10]

Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility [J].

He, Qianjun ;

Shi, Jianlin .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (16) :5845-5855

← 1 2 3 4 →