Regioselective Rh-catalyzed allylic amination/ring-closing metathesis approach to monocyclic azacycles: Diastereospecific construction of 2,5-disubstituted pyrrolines

被引：64

作者：

Evans, PA ^{[1
]}

Robinson, JE ^{[1
]}

机构：

[1] Univ Delaware, Dept Chem & Biochem, Brown Lab, Newark, DE 19716 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 12期

关键词：

D O I：

10.1021/ol991064l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Regioselective rhodium-catalyzed allylic amination followed by ring closing metathesis, using the Grubbs' catalyst, provides an expeditious route to monosubstituted azacycles, The enantiomerically enriched allylamine 1 can also be resubjected to the reaction sequence with (R) and (S)-2b to facilitate the diastereospecific construction of 2,5-disubstituted pyrrolines 3/4.

引用

页码：1929 / 1931

页数：3

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