Characterization of cortical spreading depression by imaging of intrinsic optical signals

被引:27
作者
Yoon, RS
Tsang, PW
Lenz, FA
Kwan, HC
机构
[1] UNIV TORONTO,DEPT PHYSIOL,TORONTO,ON M5S 1A8,CANADA
[2] JOHNS HOPKINS UNIV HOSP,DEPT NEUROSURG,BALTIMORE,MD 21205
关键词
cerebral cortex; imaging; intrinsic optical signals; rat; spreading depression;
D O I
10.1097/00001756-199611040-00052
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE spatiotemporal progression of cortical spreading depression was investigated by imaging of activity-dependent intrinsic optical signals in rat sensorimotor cortex. In contrast to the traditional conception of a uniformly propagating event, the evolution of the spreading depression was characterized by an asymmetrical propagating wavefront and a non-uniform dispersion of optical signals behind the wavefront. As these optical signals are a reflection of underlying molecular and metabolic processes, the imaging approach to spreading depression might constitute a useful technique for investigating the functional organization as well the pathophysiology of the cerebral cortex.
引用
收藏
页码:2671 / 2674
页数:4
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