A new ligand containing a unique combination of backbone- and P-centered chirality:: synthesis, resolution and asymmetric catalysis using a chiral enantiopure 2,2′-biphospholene

被引：25

作者：

Bienewald, F ^{[1
]}

Ricard, L ^{[1
]}

Mercier, F ^{[1
]}

Mathey, F ^{[1
]}

机构：

[1] Ecole Polytech, DCPH, Lab Heteroelements & Coordinat, CNRS,UMR 7633, F-91128 Palaiseau, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(99)00547-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiopure 2,2'-bi(1-phenyl-3,4-dimethyl-2,5-dihydro-1H-phosphole) has been synthesized and tested in the rhodium-catalyzed asymmetric hydrogenation of alpha-acetamidocinnamic acid. Enantioselectivities up to 75% have been achieved. The absolute configuration of the biphospholene was determined by X-ray diffraction methods on a crystalline tungsten carbonyl derivative. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4701 / 4707

页数：7

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