Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model

被引：24

作者：

Bermudez, LE

Nash, KA

Petrofsky, M

Young, LS

Inderlied, CB

机构：

[1] CHILDRENS HOSP,DEPT PATHOL & LAB MED,LOS ANGELES,CA

[2] UNIV SO CALIF,LOS ANGELES,CA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 174卷 / 06期

关键词：

D O I：

10.1093/infdis/174.6.1218

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An animal model was developed for studying macrolide-resistant Mycobacterium avium complex (MAC) and to measure the effect of ethambutol on resistance, MAC-infected beige mice were given clarithromycin daily; the frequency of clarithromycin-resistant MAC after 8 and 12 weeks was 10(-3) and 10(-2), respectively. Combined ethambutol plus clarithromycin did not increase anti-MAC activity, but clarithromycin-resistant MAC was less frequent (P < .05), The frequency of clarithromycin-resistant MAC in mice receiving the combination was significantly higher than that in untreated mice, These results are consistent with two human trials, which showed that adding ethambutol reduced the frequency of clarithromycin-resistant MAC. Results of the present study suggest that with an initially high level of MAC infection, the addition of ethambutol may only delay resistance, This mouse test system will be useful for investigating the influence of the level of MAC infection and the effect of other drugs on the frequency of resistant MAC.

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页码：1218 / 1222

页数：5

相关论文

共 20 条

[1] CLARITHROMYCIN, DAPSONE, AND A COMBINATION OF BOTH USED TO TREAT OR PREVENT DISSEMINATED MYCOBACTERIUM-AVIUM INFECTION IN BEIGE MICE [J].

BERMUDEZ, LE ;

INDERLIED, CB ;

KOLONOSKI, P ;

PETROFSKY, M ;

YOUNG, LS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (12) :2717-2721

[2] CLARITHROMYCIN THERAPY FOR BACTEREMIC MYCOBACTERIUM-AVIUM COMPLEX DISEASE - A RANDOMIZED, DOUBLE-BLIND, DOSE-RANGING STUDY IN PATIENTS WITH AIDS [J].

CHAISSON, RE ;

BENSON, CA ;

DUBE, MP ;

HEIFETS, LB ;

KORVICK, JA ;

ELKIN, S ;

SMITH, T ;

CRAFT, JC ;

SATTLER, FR ;

STOOL, EW ;

MACGREGOR, RR ;

BUEHNER, T ;

WU, AW ;

BARNES, GL ;

BECKER, R ;

URBANSKI, P ;

RICHARDSON, W ;

HAFNER, R ;

DIXON, D ;

FEIGAL, DW ;

DELLERSON, M ;

GUPTA, S ;

HENRY, D ;

SCHLAGER, S .

ANNALS OF INTERNAL MEDICINE, 1994, 121 (12) :905-911

[3] ACTIVITY OF AZITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN BEIGE MICE [J].

CYNAMON, MH ;

KLEMENS, SP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) :1611-1613

[4] ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL [J].

DAUTZENBERG, B ;

TRUFFOT, C ;

LEGRIS, S ;

MEYOHAS, MC ;

BERLIE, HC ;

MERCAT, A ;

CHEVRET, S ;

GROSSET, J .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (03) :564-569

[5]

DUBE M, 1996, 3 INT C MACR AZ STRE

[6] INVITRO AND INVIVO ACTIVITIES OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM [J].

FERNANDES, PB ;

HARDY, DJ ;

MCDANIEL, D ;

HANSON, CW ;

SWANSON, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1531-1534

[7] CLARITHROMYCIN MINIMAL INHIBITORY AND BACTERICIDAL CONCENTRATIONS AGAINST MYCOBACTERIUM-AVIUM [J].

HEIFETS, LB ;

LINDHOLMLEVY, PJ ;

COMSTOCK, RD .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (04) :856-858

[8] CURRENT CONCEPTS - MYCOBACTERIUM-AVIUM COMPLEX INFECTION IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

HORSBURGH, CR .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (19) :1332-1338

[9] INVITRO AND INVIVO ACTIVITY OF AZITHROMYCIN (CP-62,993) AGAINST THE MYCOBACTERIUM-AVIUM COMPLEX [J].

INDERLIED, CB ;

KOLONOSKI, PT ;

WU, M ;

YOUNG, LS .

JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (05) :994-997

[10] THE MYCOBACTERIUM-AVIUM COMPLEX [J].

INDERLIED, CB ;

KEMPER, CA ;

BERMUDEZ, LEM .

CLINICAL MICROBIOLOGY REVIEWS, 1993, 6 (03) :266-310