Advances in gene delivery through molecular design of cationic lipids

被引：252

作者：

Bhattacharya, Santanu ^{[1
,2
]}

Bajaj, Avinash ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Chem Biol Unit JNCASR, Bangalore 560064, Karnataka, India

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 31期

关键词：

ANGLE-NEUTRON-SCATTERING; LIPOSOME-DNA COMPLEXES; CELL-TRANSFECTION PROPERTIES; FATTY-ACID CHAINS; TRANSFER IN-VIVO; GEMINI SURFACTANTS; PLASMID DNA; VESICLE FORMATION; EFFICIENT TRANSFECTION; AGGREGATION PROPERTIES;

D O I：

10.1039/b900666b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

引用

收藏

页码：4632 / 4656

页数：25

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