Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review

被引:57
作者
Cervino, Gabriele [1 ]
Fiorillo, Luca [1 ]
Herford, Alan Scott [2 ]
Romeo, Umberto [3 ]
Bianchi, Alberto [4 ,5 ]
Crimi, Salvatore [4 ,5 ]
D'Amico, Cesare [1 ]
De Stefano, Rosa [1 ]
Troiano, Giuseppe [6 ,7 ]
Santoro, Rossella [8 ]
Laino, Luigi [8 ]
Laino, Gregorio [8 ]
Cicciu, Marco [1 ]
机构
[1] Messina Univ, Dept Biomed & Dent Sci & Morphol & Funct Imaging, I-98100 Messina, Italy
[2] Loma Linda Univ, Dept Maxillofacial Surg, Loma Linda, CA 92354 USA
[3] Sapienza Univ Rome, Paediat Dent Unit, Dept Oral & Maxillofacial Sci, I-00161 Rome, Italy
[4] Univ Catania, Dept Maxillofacial Surg, I-98100 Catania, Italy
[5] Univ Catania, Surg Disciplines, I-98100 Catania, Italy
[6] Univ Foggia, Dept Clin Med, I-71121 Foggia, Italy
[7] Univ Foggia, Dept Expt Med, I-71121 Foggia, Italy
[8] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Odontostomatol, I-80121 Naples, Italy
关键词
CANCER; RISK;
D O I
10.1155/2019/8040361
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Backgrounds. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. Methods. A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo. Results. The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision. Conclusion. All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose.
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页数:11
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