Halichlorine, an inhibitor of VCAM-1 induction from the marine sponge Halichondria okadai Kadota

被引：144

作者：

Kuramoto, M

Tong, C

Yamada, K

Chiba, T

Hayashi, Y

Uemura, D

机构：

[1] SHIZUOKA UNIV,FAC SCI,DEPT CHEM,SHIZUOKA 422,JAPAN

[2] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 22期

关键词：

D O I：

10.1016/0040-4039(96)00703-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel alkaloid halichlorine was isolated from Halichondria okadai Kadota and its structure was elucidated by spectroscopic analysis. The relative stereochemistry was clarified by a detailed analysis of coupling constants and the NOESY spectrum. Halichlorine significantly inhibits VCAM-1 induction in cultured HUVE (human umbilical vein endothelial) cells. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3867 / 3870

页数：4

共 10 条

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