The clone size of peripheral CD8 T cells is regulated by TCR promiscuity

被引：35

作者：

Hao, Yi ^{[1
]}

Legrand, Nicolas ^{[1
]}

Freitas, Antonio A. ^{[1
]}

机构：

[1] Inst Pasteur, CNRS, Unite Rech Associe, Unite Biol Populat Lymphocytaires, F-75724 Paris 15, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 07期

关键词：

D O I：

10.1084/jem.20052174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)-major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow exactly the same rules. We studied peripheral T cell survival and clone sizes in conditions of progressive reduction of restricting MHC-bearing cells or progressive ablation of different MHC molecules. Different CD8(+) T cell clones/polyclonal populations showed different survival and/or lymphopenia-driven proliferation requirements. We could correlate clone sizes to the capacity of each TCR to interact with different types of MHC complexes. Thus, although repertoire selection in the thymus is mainly conditioned by the affinity of TCR-MHC interactions, peripheral selection is determined by TCR cross-reactivity to environmental ligands.

引用

页码：1643 / 1649

页数：7

共 22 条

[1] Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells [J].