NF-κB and the innate immune response

被引：384

作者：

Hatada, EN ^{[1
]}

Krappmann, D ^{[1
]}

Scheidereit, C ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)00050-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappa B (NF kappa B). NF-kappa B has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappa B have been clarified by gene inactivation and biochemical analysis.

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页码：52 / 58

页数：7

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