In Vitro and in vivo models of acute alcohol exposure

被引：68

作者：

Dolganiuc, Angela ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 10期

关键词：

Models; Acute alcohol abuse; Human; Non-human; Progress; ACUTE ETHANOL EXPOSURE; PROTEIN-KINASE-C; LIVER-INJURY; BINGE DRINKING; INTOXICATION SUPPRESSES; ESCHERICHIA-COLI; OXIDATIVE STRESS; BARRIER FUNCTION; RAT HEPATOCYTES; ANIMAL-MODELS;

D O I：

10.3748/wjg.15.1168

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research. (c) 2009 The WJG Press and Baishideng. All rights reserved.

引用

页码：1168 / 1177

页数：10

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