The cancer genome

被引：2449

作者：

Stratton, Michael R. ^{[1
,2
]}

Campbell, Peter J. ^{[1
,3
]}

Futreal, P. Andrew ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England

[2] Inst Canc Res, Sutton SM2 5NG, Surrey, England

[3] Univ Cambridge, Dept Haematol, Cambridge CB2 2XY, England

来源：

NATURE | 2009年 / 458卷 / 7239期

基金：

英国惠康基金;

关键词：

COLORECTAL CANCERS; HUMAN BREAST; SOMATIC MUTATIONS; LUNG-CANCER; LEUKEMIA; PATHWAYS; GENES; THERAPY; TUMORS; SUSCEPTIBILITY;

D O I：

10.1038/nature07943

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

引用

页码：719 / 724

页数：6

共 60 条

[1]

[Anonymous], 2007, Global Cancer Facts and Figures 2007

[2] STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III [J].

Avery, Oswald T. ;

MacLeod, Colin M. ;

McCarty, Maclyn .

JOURNAL OF EXPERIMENTAL MEDICINE, 1944, 79 (02) :137-158

[3] Mutational analysis of the tyrosine kinome in colorectal cancers [J].

Bardelli, A ;

Parsons, DW ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Saha, S ;

Markowitz, S ;

Willson, JKV ;

Parmigiani, G ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2003, 300 (5621) :949-949

[4] Genetic progression and the waiting time to cancer [J].

Beerenwinkel, Niko ;

Antal, Tibor ;

Dingli, David ;

Traulsen, Arne ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Vogelstein, Bert ;

Nowak, Martin A. .

PLOS COMPUTATIONAL BIOLOGY, 2007, 3 (11) :2239-2246

[5] Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution [J].

Bignell, Graham R. ;

Santarius, Thomas ;

Pole, Jessica C. M. ;

Butler, Adam P. ;

Perry, Janet ;

Pleasance, Erin ;

Greenman, Chris ;

Menzies, Andrew ;

Taylor, Sheila ;

Edkins, Sarah ;

Campbell, Peter ;

Quail, Michael ;

Plumb, Bob ;

Matthews, Lucy ;

Mclay, Kirsten ;

Edwards, Paul A. W. ;

Rogers, Jane ;

Wooster, Richard ;

Futreal, P. Andrew ;

Stratton, Michael R. .

GENOME RESEARCH, 2007, 17 (09) :1296-1303

[6] Genetic instability is not a requirement for tumor development [J].

Bodmer, Walter .

CANCER RESEARCH, 2008, 68 (10) :3558-3560

[7]

BOVERI T., 1914, FRAGEN ENSTEHUNG MAL, P1

[8] Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment [J].

Cahill, Daniel P. ;

Levine, Kymberly K. ;

Betensky, Rebecca A. ;

Codd, Patrick J. ;

Romany, Candice A. ;

Reavie, Linsey B. ;

Batchelor, Tracy T. ;

Futreal, P. Andrew ;

Stratton, Michael R. ;

Curry, William T. ;

Iafrate, A. John ;

Louis, David N. .

CLINICAL CANCER RESEARCH, 2007, 13 (07) :2038-2045

[9] Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing [J].

Campbell, Peter J. ;

Pleasance, Erin D. ;

Stephens, Philip J. ;

Dicks, Ed ;

Rance, Richard ;

Goodhead, Ian ;

Follows, George A. ;

Green, Anthony R. ;

Futreal, P. Andy ;

Stratton, Michael R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :13081-13086

[10] Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing [J].

Campbell, Peter J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

O'Meara, Sarah ;

Li, Heng ;

Santarius, Thomas ;

Stebbings, Lucy A. ;

Leroy, Catherine ;

Edkins, Sarah ;

Hardy, Claire ;

Teague, Jon W. ;

Menzies, Andrew ;

Goodhead, Ian ;

Turner, Daniel J. ;

Clee, Christopher M. ;

Quail, Michael A. ;

Cox, Antony ;

Brown, Clive ;

Durbin, Richard ;

Hurles, Matthew E. ;

Edwards, Paul A. W. ;

Bignell, Graham R. ;

Stratton, Michael R. ;

Futreal, P. Andrew .

NATURE GENETICS, 2008, 40 (06) :722-729

← 1 2 3 4 5 6 →