Two distinctive antinociceptive systems in rats with pathological pain

被引：86

作者：

Mao, J

Price, DD

Lu, J

Keniston, L

Mayer, DJ

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Anesthesia & Crit Care,MGH Pain Ctr, Boston, MA 02114 USA

[2] Univ Florida, Hlth Sci Ctr, Gainesville, FL 32610 USA

[3] Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Med Coll Virginia, Dept Anat, Richmond, VA 23298 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 280卷 / 01期

关键词：

antinociception; cannabinoids; morphine; pathological pain;

D O I：

10.1016/S0304-3940(99)00998-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A common obstacle in clinical management of pathological pain is the poor response to opioid analgesics. We now report that Delta(9)-tetrahydrocannabinol (Delta(9)-THC)-induced antinociception remained effective in rats with pathological pain. The selective central cannabinoid receptor antagonist SR141716A, but not the generic opioid receptor antagonist naloxone, blocked the Delta(9)-THC antinociception. Moreover, there is no cross-tolerance between the antinociceptive effects of morphine and Delta(9)-THC in pathological pain states. The results indicate that Delta(9)-THC antinociception is both effective and independent of opioid receptors in rats with pathological pain. Thus, the cannabinoid analgesic system may be superior to opioids in alleviating intractable pathological pain syndromes. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

共 18 条

[1] LACK OF ANALGESIC EFFECT OF OPIOIDS ON NEUROPATHIC AND IDIOPATHIC FORMS OF PAIN [J].