Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses

被引：177

作者：

Kienesberger, Sabine ^{[1
,3
,4
]}

Cox, Laura M. ^{[1
,2
]}

Livanos, Alexandra ^{[1
]}

Zhang, Xue-Song ^{[2
]}

Chung, Jennifer ^{[1
]}

Perez-Perez, Guillermo I. ^{[1
,2
]}

Gorkiewicz, Gregor ^{[4
]}

Zechner, Ellen L. ^{[3
]}

Blaser, Martin J. ^{[1
,2
,5
]}

机构：

[1] NYU, Langone Med Ctr, Dept Med, New York, NY 10010 USA

[2] NYU, Langone Med Ctr, Dept Microbiol, New York, NY 10010 USA

[3] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[4] Med Univ Graz, Inst Pathol, A-8043 Graz, Austria

[5] VA Med Ctr, New York, NY 10010 USA

来源：

CELL REPORTS | 2016年 / 14卷 / 06期

关键词：

REGULATORY T-CELLS; BARRETTS-ESOPHAGUS; CONFER PROTECTION; IMMUNE TOLERANCE; COLONIZATION; TH17; PERSISTENCE; COMMUNITY; BACTERIA; GHRELIN;

D O I：

10.1016/j.celrep.2016.01.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.

引用

收藏

页码：1395 / 1407

页数：13

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