Oxidative stress in prostate cancer

被引：428

作者：

Khandrika, Lakshmipathi ^{[1
]}

Kumar, Binod ^{[1
]}

Koul, Sweaty ^{[1
]}

Maroni, Paul ^{[1
]}

Koul, Hari K. ^{[1
,2
]}

机构：

[1] Univ Colorado Denver, Signal Transduct & Mol Urol Lab, Program Urosci, Div Urol,Dept Surg,Sch Med,Hlth Sci Ctr, Aurora, CO 80045 USA

[2] Univ Colorado Denver, Univ Colorado, Ctr Comprehens Canc, Aurora, CO 80045 USA

来源：

CANCER LETTERS | 2009年 / 282卷 / 02期

关键词：

Reactive oxygen species; Oxidative stress; Prostate cancer; Aging; Mitochondrial DNA mutation; MITOCHONDRIAL-DNA MUTATIONS; ESTROGEN-RECEPTOR-ALPHA; ANDROGEN RECEPTOR; VITAMIN-E; HYDROGEN-PEROXIDE; MTDNA MUTATIONS; BETA-CAROTENE; NOX ENZYMES; EXPRESSION; INFLAMMATION;

D O I：

10.1016/j.canlet.2008.12.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

As prostate cancer and aberrant changes in reactive oxygen species (ROS) become more common with aging, ROS signaling may play an important role in the development and progression of this malignancy. Increased ROS, otherwise known as oxidative stress is a, result of either increased ROS generation or a loss of antioxidant defense mechanisms. Oxidative stress is associated with several pathological conditions including inflammation and infection. ROS are products of normal cellular metabolism and play vital roles in stimulation of signaling pathways in response to changing intra- and extracellular environmental conditions. Chronic increases in ROS over time are known to induce somatic mutations and neoplastic transformation. In this review we summarize the causes for increased ROS generation and its potential role in etiology and progression of prostate cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：125 / 136

页数：12

共 113 条

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