Heterochromatin revisited

被引：1034

作者：

Grewal, Shiv I. S. ^{[1
]}

Jia, Songtao ^{[1
]}

机构：

[1] NCI, Mol Cell Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrg2008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.

引用

页码：35 / 46

页数：12

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