DNA hypermethylation in breast cancer and its association with clinicopathological features

被引：83

作者：

Li, ShaoYing ^{[1
]}

Rong, Minna ^{[1
]}

Iacopetta, Barry ^{[1
]}

机构：

[1] Univ Western Australia, Sch Surg & Pathol, Nedlands, WA 6009, Australia

来源：

CANCER LETTERS | 2006年 / 237卷 / 02期

关键词：

methylation; breast cancer; histological grade; tumour suppressor gene;

D O I：

10.1016/j.canlet.2005.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant hypermethylation of gene promoter regions is one of the mechanisms for inactivation of tumour suppressor genes in breast cancer. We investigated whether hypermethylation identifies breast cancers with distinctive clinical and pathological features. We evaluated the methylation of RAR beta 2, CDH1, ER, BRCA1, CCND2, p16 and TWIST in 193 breast carcinomas. Methylation frequencies ranged from 11% for CCND2 to 84% for ER. Tumours with frequent methylation (4-6 genes) were more often poorly differentiated compared to those with infrequent methylation (0-2 genes; P=0.004). Tumours with ER and CDH1 methylation were associated with significantly lower hormone receptor levels, younger age at diagnosis and the presence of mutant p53. Our data suggests that gene methylation may be linked to various pathological features of breast cancer, however, this requires confirmation in larger studies. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：272 / 280

页数：9

共 45 条

[1] Microsatellite instability in hereditary and sporadic breast cancers [J].

Adem, C ;

Soderberg, CL ;

Cunningham, JM ;

Reynolds, C ;

Sebo, TJ ;

Thibodeau, SN ;

Hartmann, LC ;

Jenkins, RB .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (04) :580-582

[2]

Anbazhagan R, 1999, CLIN CANCER RES, V5, P839

[3] Hypermethylation in histologically distinct classes of breast cancer [J].

Bae, YK ;

Brown, A ;

Garrett, E ;

Bornman, D ;

Fackler, MJ ;

Sukumar, S ;

Herman, JG ;

Gabrielson, E .

CLINICAL CANCER RESEARCH, 2004, 10 (18) :5998-6005

[4] Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer [J].

Bianco, T ;

Chenevix-Trench, G ;

Walsh, DCA ;

Cooper, JE ;

Dobrovic, A .

CARCINOGENESIS, 2000, 21 (02) :147-151

[5] Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer:: correlation with disease characteristics [J].

Catteau, A ;

Harris, WH ;

Xu, CF ;

Solomon, E .

ONCOGENE, 1999, 18 (11) :1957-1965

[6] Methylation target array for rapid analysis of CpG island hype rmethyl ation in multiple tissue genomes [J].

Chen, CM ;

Chen, HL ;

Hsiau, THC ;

Hsiau, AHA ;

Shi, HD ;

Brock, GJR ;

Wei, SH ;

Caldwell, CW ;

Yan, PS ;

Huang, THM .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (01) :37-45

[7] Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors [J].

Esteller, M ;

Silva, JM ;

Dominguez, G ;

Bonilla, F ;

Matias-Guiu, X ;

Lerma, E ;

Bussaglia, E ;

Prat, J ;

Harkes, IC ;

Repasky, EA ;

Gabrielson, E ;

Schutte, M ;

Baylin, SB ;

Herman, JG .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (07) :564-569

[8] Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR [J].

Evron, E ;

Dooley, WC ;

Umbricht, CB ;

Rosenthal, D ;

Sacchi, N ;

Gabrielson, E ;

Soito, AB ;

Hung, DT ;

Ljung, BM ;

Davidson, NE ;

Sukumar, S .

LANCET, 2001, 357 (9265) :1335-1336

[9]

Evron E, 2001, CANCER RES, V61, P2782

[10] Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer [J].

Fackler, MJ ;

McVeigh, M ;

Mehrotra, J ;

Blum, MA ;

Lange, J ;

Lapides, A ;

Garrett, E ;

Argani, P ;

Sukumar, S .

CANCER RESEARCH, 2004, 64 (13) :4442-4452

← 1 2 3 4 5 →