N-alkyl-4-1(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]-benzamides, μ and δ opioid agonists:: a μ address

被引：5

作者：

Carson, JR ^{[1
]}

Coats, SJ ^{[1
]}

Codd, EE ^{[1
]}

Dax, SL ^{[1
]}

Lee, J ^{[1
]}

Martinez, RP ^{[1
]}

McKown, LA ^{[1
]}

Neilson, LA ^{[1
]}

Pitis, PM ^{[1
]}

Wu, WN ^{[1
]}

Zhang, SP ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Drug Discovery, Spring House, PA 19477 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期

关键词：

D O I：

10.1016/j.bmcl.2004.02.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The tertiary amide 6 opioid agonist 2 is a potent antinociceptive agent. Compound 2 was metabolized in vitro and in vivo to secondary amide 3, a potent and selective p opioid agonist. The SAR of a series of N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylid-ene)phenylmethyl]benzamides was examined. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2113 / 2116

页数：4

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