Bioavailable Insulin-like Growth Factor-I Inversely Related to Weight Gain in Postmenopausal Women Regardless of Exogenous Estrogen

被引:6
作者
Jung, Su Yon [1 ]
Hursting, Stephen D. [3 ]
Guindani, Michele [2 ]
Vitolins, Mara Z. [4 ]
Paskett, Electra [5 ]
Chang, Shine [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
[3] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA
[4] Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27109 USA
[5] Ohio State Univ, Coll Med, Div Canc Prevent & Control, Columbus, OH 43210 USA
关键词
FACTOR BINDING PROTEIN-3; CLINICAL-RESEARCH CENTER; TRANSDERMAL ESTROGEN; BREAST-CANCER; MAMMOGRAPHIC DENSITY; METABOLIC PARAMETERS; DIETARY INTERVENTION; HORMONE SECRETION; PHYSICAL-ACTIVITY; BODY-COMPOSITION;
D O I
10.1158/1055-9965.EPI-13-1053
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Background: Weight gain, insulin-like growth factor-I (IGF-I) levels, and excess exogenous steroid hormone use are putative cancer risk factors, yet their interconnected pathways have not been fully characterized. This cross-sectional study investigated the relationship between plasma IGF-I levels and weight gain according to body mass index (BMI), leptin levels, and exogenous estrogen use among postmenopausal women. Methods: This study included 794 postmenopausal women who enrolled in an ancillary study of the Women's Health Initiative Observational Study between February 1995 and July 1998. The relationship between IGF-I levels and weight gain was analyzed using ordinal logistic regression. We used the molar ratio of IGF-I to IGF binding protein-3 (IGF-I/IGFBP-3) or circulating IGF-I levels adjusting for IGFBP-3 as a proxy of bioavailable IGF-I. The plasma concentrations were expressed as quartiles. Results: Among the obese group, women in the third quartile (Q3) of IGF-I and highest quartile of IGF-I/IGFBP-3 were less likely to gain weight (>3% from baseline) than were women in the first quartiles (Q1). Among the normal-weight group, women in Q2 and Q3 of IGF-I/IGFBP-3 were 70% less likely than those in Q1 to gain weight. Among current estrogen users, Q3 of IGF-I/IGFBP-3 had 0.5 times the odds of gaining weight than Q1. Conclusions: Bioavailable IGF-I levels were inversely related to weight gain overall. Impact: Although weight gain was not consistent with increases in IGF-I levels among postmenopausal women in this report, avoidance of weight gain as a strategy to reduce cancer risk maybe recommended. (C) 2013 AACR.
引用
收藏
页码:534 / 544
页数:11
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