Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

被引：20

作者：

Bach, Peter

Nilsson, Karolina

Svensson, Tor

Bauer, Udo

Harnmerland, Lance G.

Peterson, Alecia

Wallberg, Andreas

Osterlund, Krister

Karis, David

Boije, Maria

Wensbo, David

机构：

[1] AstraZeneca R&D, Dept Med Chem, S-43183 Molndal, Sweden

[2] NPS Pharmaceut, Salt Lake City, UT 84108 USA

[3] AstraZeneca R&D Sodertalje, Dept Med Chem, Local Discovery CNS & Pain Control, S-15185 Sodertalje, Sweden

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期

关键词：

mGluR5; antagonists; pyridinyl-alkynes; SAR; gastro-esophageal reflux disease (GERD);

D O I：

10.1016/j.bmcl.2006.06.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4788 / 4791

页数：4

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