Localization of mRNAs for phospholipase D (PLD) type 1 and 2 in the brain of developing and mature rat

被引：29

作者：

Saito, S ^{[1
]}

Sakagami, H ^{[1
]}

Kondo, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med Sci, Dept Cell Biol, Div Histol,Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2000年 / 120卷 / 01期

关键词：

phosphatidylcholine-specific phospholipase D; brain; glia; rat; in situ hybridization histochemistry;

D O I：

10.1016/S0165-3806(99)00189-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phospholipase D (PLD) is known as one of the key enzymes in the lipid metabolism which produces several second messengers. We demonstrated the localization of the gene expression for PLD1 and PLD2 using in situ hybridization histochemistry in the brain of developing and mature rats. Whereas PLD1 mRNA expression was detected mainly in presumptive origodendrocytes, PLD2 mRNA expression was detected mainly in presumptive astrocytes. In addition, the gene expression for PLDs were expressed in neuroepithelial cells of the ventricular/ependymal zones and the gene for PLD2 was expressed transiently in early postnatal gray matters, presumptive neurons. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：41 / 47

页数：7

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