Total synthesis of macrosphelides B and A

被引：35

作者：

Kobayashi, Y ^{[1
]}

Kumar, BG ^{[1
]}

Kurachi, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期

关键词：

biologically active compounds; macrosphelide B; macrosphelide A; macrolide; oxidation of furans; stereocontrol;

D O I：

10.1016/S0040-4039(99)02323-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient total synthesis of macrosphelide B has been developed in which the C(5)-O(10) and the C(11)-O(16) fragments were prepared from (S)-1-(2-furyl)ethanol of >98% ee via oxidation of the furan part. In addition, macrosphelide B was transformed stereoselectively into macrosphelide A by reduction followed by Mitsunobu inversion. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

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页码：1559 / 1563

页数：5

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