Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol)

被引：322

作者：

Ignatova, Milena

Starbova, Kirilka

Markova, Nadya

Manolova, Nevena

Rashkov, Iliya ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Polymers, Lab Bioact Polymers, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Cent Lab Photoproc, BU-1113 Sofia, Bulgaria

[3] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria

来源：

CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 12期

关键词：

electrospinning; chitosan derivatives; photo-mediated cross-linking; water-stable nano-fibrous mats; antibacterial activity;

D O I：

10.1016/j.carres.2006.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Nano-fibres containing quaternised chitosan (QCh) have been successfully prepared by electrospinning of QCh solutions mixed with poly(vinyl alcohol) (PVA). The average fibre diameter is in the range of 60-200 nm. UV irradiation of the composite electrospun nano-fibrous mats containing triethylene glycol diacrylate as cross-linking agent has resulted in stabilising of the nano-fibres against disintegration in water or water vapours. Microbiological screening has demonstrated the antibacterial activity of the photo-cross-linked electrospun mats against Staphylococcus aureus and Escherichia coli. The obtained nano-fibrous electrospun mats are promising for wound-heating applications. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2098 / 2107

页数：10

共 30 条

[1]

[Anonymous], BIOCH ANTIMICROBIAL

[2]

Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin [J].